Pattern of Regional Cortical Thinning Associated with Cognitive Deterioration in Parkinson’s Disease
نویسندگان
چکیده
منابع مشابه
Pattern of Regional Cortical Thinning Associated with Cognitive Deterioration in Parkinson’s Disease
BACKGROUND Dementia is a frequent and devastating complication in Parkinson's disease (PD). There is an intensive search for biomarkers that may predict the progression from normal cognition (PD-NC) to dementia (PDD) in PD. Mild cognitive impairment in PD (PD-MCI) seems to represent a transitional state between PD-NC and PDD. Few studies have explored the structural changes that differentiate P...
متن کاملCortical thinning associated with mild cognitive impairment in Parkinson's disease.
The aim of this study was to investigate patterns of cortical atrophy associated with mild cognitive impairment in a large sample of nondemented Parkinson's disease (PD) patients, and its relation with specific neuropsychological deficits. Magnetic resonance imaging (MRI) and neuropsychological assessment were performed in a sample of 90 nondemented PD patients and 32 healthy controls. All unde...
متن کاملRegional cortical thinning associated with detectable levels of HIV DNA.
High levels of human immunodeficiency virus (HIV) DNA in peripheral blood mononuclear cells (PBMCs), and specifically within CD14+ blood monocytes, have been found in HIV-infected individuals with neurocognitive impairment and dementia. The failure of highly active antiretroviral therapy (HAART) to eliminate cognitive dysfunction in HIV may be secondary to persistence of HIV-infected PBMCs whic...
متن کاملGlobal and regional cortical thinning in first-episode psychosis patients: relationships with clinical and cognitive features.
BACKGROUND The thickness of the cortical mantle is a sensitive measure for identifying alterations in cortical structure. We aimed to explore whether first episode schizophrenia patients already show a significant cortical thinning and whether cortical thickness anomalies may significantly influence clinical and cognitive features. METHOD We investigated regional changes in cortical thickness...
متن کاملRegional cortical thinning in multiple sclerosis and its relation with cognitive impairment: A multicenter study.
OBJECTIVES The objectives of this paper are to compare in a multicenter setting patterns of regional cortical thickness in patients with relapsing-remitting multiple sclerosis (RRMS) and cognitive impairment (CI) and those cognitively preserved (CP), and explore the relationship between cortical thinning and cognitive performance. METHODS T1-weighted isotropic brain scans were collected at 3T...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: PLoS ONE
سال: 2013
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0054980